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KMID : 0370219880320030170
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Yakhak Hoeji
1988 Volume.32 No. 3 p.170 ~ p.176
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Separation of Amino Acid Enantiomers by Gas Chromatogaphy on Phenylthiohydantoin Derivatives as Chiral Stationary Phases
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Abstract
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The resolution of five amino acids derivatives by gas chromatography on phenylthiohydantoin derivatives as chiral stastionary phase was investigated. (S)-5-isopropyl, isobutyl, (sec)-butyl and benzoyl derivatives of N3-phenyl-2-thiohydantoin were synthesized from L-valine, L-leucine, L-isoleucine and L-phenylalanine, respectively. The phases were employed at several column temperatures (140°CN210°C). The separation factors were compared with each stationary phase with varying R groups. The possible mechanism of chiral recognition was investigated by NMR technique.
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